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Current Cooperations

IMEDOS has strong historical ties to scientists and researchers around the world. Here you will find a selection of our current collaborations :

-> Augenklinik der Universitätsmedizin der Johann Gutenberg Universität in Mainz

-> Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie - Kliniken Essen-Mitte



Ophthalmology Department of J. Gutenberg University Medical Center in Mainz

PD Dr. med. Alireza Mirshahi
Position (task): Assistant Medical Director

Gutenberg Health Study (GHS) 

The Gutenberg Health Study (GHS) is a population-based, prospective, observational cohort study in the Rhine-Main region in midwestern Germany with a total of 15000 participants and follow-up after five years. The study sample is being recruited from subjects aged between 35 and 74 years. An important feature of the study design is the interdisciplinary combination of an ophthalmological examination, general and especially cardiovascular examinations, psychosomatic evaluation, laboratory tests, and biobanking for proteomic and genetic analyses. All participants undergo a 25-minute ophthalmological examination including a medical history of eye diseases, autorefraction and visual acuity, IOP measurement, visual field screening, central corneal thickness, keratometry, slit lamp biomicroscopy and non-mydriatic fundus photography. With the entire cohort’s 5-year follow-up starting in April 2012, further tests are being introduced, including OCT, Pentacam® and laser inteferometer biometry.

Retinal vessel analyses are now being performed in cooperation with Imedos® using non-mydriatic fundus photographs. In line with the main GHS goal, the Ophthalmology Department of J. Gutenberg University Medical Center is seeking systemic and cardiovascular implications associated with changes in the retinal arterial and venous vessels. Intensive staff training and cooperation is provided by Imedos® to ensure high quality of the analyses.

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Centre of Anaesthesia, Intensive Care and Pain Management - Kliniken Essen-Mitte

Prof. Dr. med. H. Groeben

Director of the Centre of Anaesthesia, Intensive Care and Pain Management- Kliniken Essen-Mitte

An important focus of our research and research in the field of anesthesiology focuses on the influence of perioperative conditions on the physiology and pathophysiology of the people. Thanks to the development of new surgical procedures and anesthesiolocal monitoring and treatment in recent decades surgeries  become possible that were not possible due to the age of the patient (very old and very young patients) or the co-morbidities of patients. Here perioperative conditions have been established which burdens the organism for the period of operation extreme loads. For example, for robot-assisted surgery in urology a patient usually of advanced age  spends several hours in a head-low position of 45° and in addition a pneumoperitoneum will be created with gas pressure 12-20 mmHg and a controlled ventilation with significantly increased respiratory printing will be performed. That these conditions are not always compensated without problems by the organism is shown in a number of cases described in recent years, cases of permanent vision loss up to blindness immediately following these operations. 1. So far among these operations a significant increase in intraocular pressure has been described only. 2. It turns the question whether other determinants of retinal perfusion can be influenced.

Due to the substantial burden it is currently not clear how far the basic physiological concepts such as the idea that the venous outflow pressure for retinal perfusion in consideration of the intraocular pressure is insignificant are appropriate yet. Therefore we ask ourselves how the retinal perfusion has dealt with head-low position and positive airway pressure.

The cooperation with Imedos Systems by using the Dynamic Vessel Analysis enabled us with the help of subjects to gain initial insights into this issueIt was found that in some of the subjects actually the intraocular pressure exceeded the venous outflow pressure and thus new considerations for monitoring of these conditions and for therapy are required.Moreover the additional measurement of venous oxygen saturation in retinal vein allows independent control of the with the DVA calculated perfusion condition because reduced perfusion could be verified in an increased utilization.

1. Shmygalev S, Heller AR: Erblindung nach nichtophthalmologischen Eingriffen. Anaesthesist 2011; 60: 683-94 

2. Awad H, Sandilli S, Ohr M, Roth A, Yan W, Fernandez S, Roth S, Patel V: The
effects of steep Trendelenburg positioning on intraocular pressure during robotic radical prostatectomy. Anesth Analg 2009;109:473-8.

CONTACT

IMEDOS Systems GmbH
Am Nasstal 4
D-07751 Jena
GERMANY

phone: +49-3641-63960
fax: +49-3641-639612

info(at)imedos.de

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