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Biosignal and mathematical modeling in retinal vessel analysis

Prof. Dr.-Ing. Konstantin Kotliar

Department of Medical Engineering and Industrial Mathematics

Fachhochschule Aachen

My research is focused on the development of new diagnostic methods and principles in the field of dynamic retinal vessel analysis for use in medicine, particularly in the field of ophthalmology, cardiovascular medicine, sports medicine and neurology. The biosignals detected in vivo with the Retinal Vessel Analyser are a gold mine for the detection of vascular pathology, for monitoring the progression of vascular disease or for the investigation of the effect of a drug on retinal microcirculation. Such high-resolution signals, namely the vessel diameter changes over time and location along the vessel, contain a lot of information about the changes in the retinal vascular regulation, blood circulation problems, stiffening of the vessel walls and vascular tone. We just need to find out which information in the RVA signal is directly clinically relevant, how to objectively deprives these quantitative information from the signal and what that means exactly.

It is my job to continue the successful cooperation with my valued colleagues from various fields of clinical medicine and the 12-year-old fruitful cooperation with the company IMEDOS Systems. The use of modern methods of biosignal processing have allowed me to help develop diagnostic methods based on the retinal vessel analysis and to test it in clinical practice.

Spontaneous retinal vascular pulsation, vascular response to physiological and pharmacological provocation, local dynamic structural vascular changes and vascular stiffness were recorded non-invasively during the examination of the patients. Significant differences were shown in the dynamic behavior of vessels in healthy patients of different ages and with systemic and ocular diseases of vascular origin. Quantitative clinical parameters have emerged which were crucial for the given vessel pathology. A set of such parameters which represent different aspects of dynamic behavior of retinal vessels should be available in the future recognizing vascular pathology, such as diabetes mellitus or hypertension using a DVA measurement for obvious early detection.

One of the latest developments by me and my colleagues allows a non-invasive quantitative assessment of pulse wave propagation in the central microcirculation, which allows to characterize the stiffness of the micro vessels throughout the body. This parameter we call "retinal pulse wave velocity" (rPWV). Our initial results are promising. They show that the parameter can be a promising early biomarker of microcirculation in the cardiovascular medicine (Kotliar et al. IOVS, 2012, 53: 2119-2126; Kotliar et al. Microcirculation, 2013, 20: 405-415).

My research prizes in the field of retinal vessel analysis:

Servier Research Award of the European Society of Hypertension (2011)

Adalbert-Buding-Research Prize of the  Deutschen Hochdruckliga and Deutschen Hypertonie Gesellschaft (2007)

International MSD Award, 1st Prize (2006)

CONTACT

IMEDOS Systems GmbH
Am Nasstal 4
D-07751 Jena
GERMANY

phone: +49-3641-63960
fax: +49-3641-639612

info(at)imedos.de

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